Segmental copy-number gains are major contributors to human genetic variation and disease, but how these alterations arise remains incompletely understood. Here, based on the analyses of both ...

We oriented the clusters by their lesion-containing strand, and designated the first mutation site to be replicated over on the lesion-containing template as the upstream (5′) mutation and subsequent ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides—whether to repair damaged tissue, replace old cells, or simply to help the ...