Mismatch repair (MMR) deficiency occurs in 10–20% of colorectal cancer (CRC) cases, leading to microsatellite instability (MSI). Although MSI/MMR testing is critical for CRC management, high costs and ...
The assessment compared tumour testing strategies involving microsatellite instability (MSI) testing, immunohistochemistry (IHC) testing (both with and without further testing to exclude sporadic ...
Testing colorectal tumours using either microsatellite instability (MSI) or immunohistochemistry (IHC) testing for mismatch repair (MMR) proteins can identify people in whom the cancer may have ...
Although the majority of patients are diagnosed with early-stage disease, outcomes remain poor for those with primary advanced or recurrent endometrial cancer, with reported 5-year survival rates as ...
Microsatellite instability (MSI) is a hallmark of defective DNA mismatch repair (MMR) and manifests as widespread length alterations in short tandem repeats throughout the genome. This hypermutability ...
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