Bacteria employ small non-coding RNAs (sRNAs) as versatile regulators of gene expression, primarily by modulating the activity of RNA polymerase and its interaction with sigma factors. These sRNAs, ...

Definition: Non-coding RNA (ncRNA) is any RNA molecule that is transcribed from DNA but is not translated into a protein. Instead of serving as a protein blueprint, the RNA molecule itself is the ...

With the advancement of next-generation sequencing technologies, transfer RNA (tRNA)-derived small RNAs (tsRNAs) have been progressively elucidated in their biogenesis and classification. tsRNAs are ...

－ストレスを受けた親が生存能力の高い子を生む仕組み－ 理化学研究所（理研）生命機能科学研究センター老化分子生物学研究チームの岡部恵美子リサーチアソシエイト、宇野雅晴研究員、西田栄介チームリーダーらの研究チームは、マイルドな環境 ...

今回、CRISPR免疫に対する新しい防御機構が報告されている。この機構は、ウイルスやプラスミドに広く見られ、小分子ノンコーディングRNA抗CRISPR（Racr：small non-coding RNA anti-CRISPR）を基盤としており、CRISPR複合体の形成を阻害する。

Small RNA therapeutics can modulate multiple genes. This ability may counter tumor adaptation and resistance, overcoming the ...

Historically, drug discovery has centred around proteins but as targets become increasing saturated, novel RNA-targeting drugs indicate potential in rare diseases and oncology. Photo by Christoph ...